Technologies

AN OUTSTANDING PORTFOLIO OF MIND AND MATTER

CHEMISTRIES

  • Asymmetric synthesis
  • Lithiation (RLi, LDA, Schlosser’s base, Li in liquid NH3)
  • Grignard (Mg/ether, AlkMgCl/ether) and low temperature Grignard (VinylMgCl/-80°C) chemistry
  • Pd-catalyzed coupling (Heck, Suzuki, Sonogashira
  • Metal hydride reduction (powder and in solution LAH, DIBAL, LiAl(O-tBu)3H, NaBH4, etc...)
  • Catalytic hydrogenation (Pd/C, Pt/C, PtO2, Ir/C) up to 12 bar
  • Asymmetric cat. hydrogen. (RhL*/RuL*; L*=chiral ligand)
  • BH3/THF reduction
  • Carbonyl asymmetric reduction ((R)-DPP/BH3)
  • (Asymmetric) reductive amination
  • TIBAL cleavage of ArO-Alk; TES cleavage of C-OH
  • N,O-Methylation and demethylation
  • Alkylation using DMS and DES
  • Eschweiler-Clarke methylation
  • Cyanation (alkali metal cyanides and substitutes)
  • Amino acids protection and derivatization
  • Ozonolysis + reductive/oxidative quench (in batch and continuous flow)
  • Chiral epoxides chemistry (synthesis and processing)
  • Chiral Epoxides Chemistry (synthesis and processing)
  • Periodate/permanganate oxidation
  • High T/P amination/aminolysis with aq./gas. NH3;

TECHNOLOGIES AVAILABLE

  • Cryogenic chemistry (-80°/-90°C)
  • Autoclaves (max. 12 bar)
  • Crystallization/Solid state engineering: large scale reactive crystallization, Spherical Agglomeration, handling of meta-stable polymorphs
  • Particle downsizing: grinding, milling, micronization
  • Spray-drying (PSD 1 and PSD 2)
  • Bulk freeze-drying (50 m2)
  • Ultra-Filtration (cut off ≥ 1000 Da)
  • Nano-Filtration (cut off ≥ 300 Da)
  • Electrodialysis
  • Wiped Film Evaporation down to 1mbar (pilot/indus. scale)
  • PAT: RAMAN and FBRM ATEX probes

ANALYTICAL CAPABILITIES AND QUALITY CONTROL

  • In-house development of new analytical methods
  • Validation and transfer of analytical methods