R&D

Research & Development

ZaCh System’s impressive R&D resources are supported by cutting edge technologies, including solid state control and analysis by X-Ray Powder Diffraction, Solid state 400 MHz NMR, NIR, RAMAN, FT-IR, Lasentec technology, DSC and TGA.

 

Thermal analysis and Process Analytical Technology (PAT) laboratory

  • Mixing and Reaction Calvet Calorimeter C 80
  • Two Mettler RC-1 Reaction Calorimeters, one with cryogenic unit
  • Integrated Thermal Analysis (TA) system consisting of (a) Modulated DSC (Tzero technology), Q100-MFC, and (b) Dynamic High-Resolution TGA
  • React-I 4000 system for the online measurement of reaction kinetics
  • Lasentec probe for crystallization optimization and control
  • TGA controlled IR-NIR-RAMAN spectrometry platform




cGMP Kilolab Operations Laboratories

  • cGMP kilolabs designed to face the increasing demand of preparing advanced intermediates and API samples in amounts of 1 to 5 kg
  • Compliance with all relevant cGMP and ISO standards, allowing the preparation of samples for pre-clinical and early-phase clinical studies
  • Versatile reactor technologies enabling very complex chemical and technological processes to be handled with ease
  • Class 100,000/10,000 finishing area (computer-controlled treatment)




Comprehensive analytical technologies

  • High-resolution analytical equipment: MS-HRGC and MS-HPLC (ion trap and electro spray)
  • Multinuclear NMR (400 MHz)
  • Bruker D 8 Advance X-Ray Diffractometer
  • Ultra performance Liquid Chromatography
  • Flexylab FT-4 (4 x 100-250 ml)
  • Full range of standard technologies, including HPLC, GC, IR and UV